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Consent for publication We confirm that the manuscript has been read and approved by all named authors, and that there are no other persons who satisfied the criteria for authorship but are not listed

Best Practices Rotate injection sites to avoid irritation Use insulin syringes (subcutaneous or intramuscular) Pair with nutrient timing include carbs + protein post-injection Avoid combining with fasted cardio or insulin-modulating agents Monitor energy, recovery, and blood sugar response Low-dose IGF-1 therapy shows beneficial effects on muscle recovery and composition without adverse metabolic effects when monitored appropriately. Juul, A

In addition, previous studies have shown that LRP1 can be combined with tissue plasminogen activator (t-PA) to promote HSC apoptosis and reverse HSC activation [41]

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