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The two are complementary in research

Instead, it appears to increase lipolysis in the body via mechanisms that are not fully elucidated

While analogs with reduced IGFBP affinity show increased potency in vitro, careful pharmacokinetic work has shown that such analogs are actually cleared more rapidly than native IGF-1 after parenteral administration in vivo, because the binding proteins that inhibit activity also serve as a circulating reservoir that prolongs systemic presence