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When incorporated into advanced delivery systems like nanostructured lipid carriers (NLCs) or solid lipid nanoparticles (SLNs) , these natural agents may enhance the therapeutic efficacy of vitamin D analogs or corticosteroids by improving skin penetration , prolonging drug release , and reducing local and systemic toxicity (Bodnr et al

Bacteria in the ilium metabolize primary bile acids and turn them into secondary bile acids

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However, in the laboratory setting it becomes evident that diluting a buffer with pure water impacts the pH of the solution