chac1 er stress glutathione degradation Functions of glutathione-degrading enzymes in tumors. The functions of CHAC1 degradation of glutathione enhances
CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Human ChaC1 but not human ChaC2 is induced specifically by ER stress Download Scientific Diagram Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications
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