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Transdermal estradiol carries a lower risk of blood clots compared to oral formulations because it bypasses first-pass hepatic metabolism

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We see it across a range of conditions but the real standout is with respect to opioid overdoses, where the rate of opioid overdose deaths for people right after they leave prison or jail is significantly higher than it is for the population as a whole. The idea behind this waiver is to mitigate the coverage gap for individuals leaving prison and ensure a better continuum of care

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