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Nan et al., 2022

In a rat hemorrhagic model of acute anemia, transfusion of anaerobically stored RBCs was superior to that of conventional RBCs in that a lower RBC volume was required in order to normalize hemodynamics (mean arterial blood pressure), a study endpoint chosen because of its adoption in clinical guidelines for trauma management including those for Advanced Trauma Life Support and from the American College of Surgeons ( Diabetes and Red Blood Cell ATP Export James and coworkers demonstrated impairment in the ability of diabetic human RBCs to vasodilate blood vessels

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