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6.2 NADPH: driving force for glutathione redox cycling The antioxidant activity of glutathione (GSH) critically relies on its regeneration from the oxidized form, glutathione disulfide (GSSG), through a reaction catalyzed by glutathione reductase (GR) that consumes NADPH

However, they also highlight a deeper, systemic challenge: ferroptosis is not a static or isolated event but a dynamic biological process intricately coupled with metabolism, redox homeostasis, and immune surveillance

It is notable that salinity appears to be among the most decisive factors for the diversity and composition of the GM: Indeed, in chinook salmon (Zhao et al., 2020a), salinity was reportedly more important than water temperature with regards to the effect on GM, and in Atlantic salmon the shift from freshwater to saltwater significantly impacted the GM while diet did not show significant associations with the microbiota (Rudi et al., 2018)

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