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However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes

10.1016/S0022-2836(02)00262-0 76 SamdaniA.VetrivelU

Clinical trials show that by day 10 to 14, the majority of patients experience measurable improvement in side effect severity

Consequently, its activity reflects the cells energy state and redox balance and can modulate mitochondrial ROS production under conditions of high NADH/NAD + ratios or impaired electron flow