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It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Sanjay et al., 2022

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota

Required Medical Stability: Patients must not have decompensated neurological conditions (e.g., advanced multiple sclerosis or Parkinsons disease), as these may affect the therapys ability to restore normal sleep patterns

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