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[0033] In some embodiments, a composition comprises about 0.01 milligrams (mg) to about 10 mg of CBD, about 0.5 mg to about 50 mg niacinamide, and about 0.1 mg and 100 mg L- ergothioneine per milliliter of composition

A pharmaceutical composition comprising: about 0.25 % to about 10 % of a reducing agent-choline ester, optionally, about 0.05 % to about 1.0 % of a biochemical energy source, about 0.25 % to about 1 % buffer, about 0.2 % to about 0.6 % tonicity agent, and about 0.1 % to about 0.4 % viscosity agent

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