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Description

Multiple studies have demonstrated that both pharmacological inhibition and genetic ablation of complex I can influence ferroptosis sensitivity in various disease contexts, including cancer, skin photoaging, Parkinsons disease and intracerebral hemorrhage 103,104,105,106

[118] However, the available evidence remains inconclusive, with methodological limitations affecting the interpretation of study results

16b) agreeing with reported values 11,25,33

Therefore, given that the solubility of LS-102 has been markedly improved compared to the precursor compound AS-IV, it can be employed as a novel synthetic drug containing carboxylic acid to treat metabolic diseases such as obesity through oral administration (21,215)