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This is not a rule, just a pattern observed across thousands of trial participants

10.3390/pharmaceutics16070932 91 MazumdarS.ChauhanA.MridhaN

While manganese could not be detected, calcium was detected with a 1:1 stoichiometry

Schematic showing how the iron-sulfur clusters-containing protein LIAS enables OGDH and PDH activity by transferring lipoic acid as a cofactor to their enzyme complexes (top left)