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Neuron 19 , 11271140 (1997)

2.2.8 Forskolin Forskolin, a labdane diterpenoid derived from Plectranthus barbatus (formerly Coleus forskohlii ), is a direct activator of adenylyl cyclase, increasing intracellular cyclic AMP (cAMP) which play a crucial role in IOP regulation, neuroprotection, and cellular signaling (219221)

The physiological effects of caffeine stem from its action on the central nervous system, where it blocks adenosine receptors, leading to increased neuronal firing and the release of neurotransmitters like dopamine and norepinephrine