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screened 1,921 patients with PD for GBA1 mutations and found that carriers of neuropathic Gaucher disease mutations and complex GBA1 alleles exhibited a more rapid decline in Mini-Mental State Examination (MMSE) scores, whereas this association was not observed in carriers of non-neuropathic mutations or risk variants [114]

Like the approach used for the discovery cohort, we next searched for additional proteins that may be indicative of differences in the same cohort using (s)PLS-DA analysis

Most studies and data focus on infertility in women, yet there has been relatively little attention given to the male contribution to infertility which may be a factor for more than half of infertile couples

Attempts to demetallate CuCP with copper-binding ligands In CuCP samples the copper eluted from the Sephadex G25 column in HMW region confirming that metal is strongly bound to the protein