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The local Institutional Review Boards (Comit de Protection des Personnes Ile de France IX) approved this study

its near-complete local consumption by normal colonocytes explains why systemic butyrate levels do not reflect colonic availability and why oral supplementation at standard doses fails to provide meaningful distal colonic delivery

Specifically, we proposed to revise the regulations at 410.32(b)(3)(ii) to state that through December 31, 2025, the presence of the physician (or other practitioner) includes virtual presence through audio/video real-time communications technology (excluding audio-only)