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Angiogenic AcSDKP generation Prolyl oligopeptidase cleaves TB4 and releases the tetrapeptide Ac-Ser-Asp-Lys-Pro, an autonomous angiogenic factor layered on top of TB4's direct effect on endothelial migration

Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

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