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L.IrwinN.VolpeJ

Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma

Although AMPK does not directly activate SIRT1, SIRT1 activity can increase with AMPK either by elevating the cellular NAD + /NADH ratio that leads to deacetylation and downstream SIRT1 target activity changes to involve peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and forkhead transcription factors (613) or through increasing NAMPT to raise NAD + and lower SIRT1 inhibitors such as nicotinamide (574)

This review focuses on the chemistry-driven evolution of delivery strategies to transform these molecular liabilities into pharmacological advantages