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We followed the criteria proposed by the 2004 US Surgeon General Report on the health consequences of smoking [32], which include the evaluation of consistency, temporality, strength, dose-response relationship, and biological plausibility including confounding

1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity

Although this approach showed promising ideas, the authors pointed out that kidney organoids in general resembled a rather immature form of the kidney and the Gb3 deposition with subsequent tissue damage in the patient takes a much longer time than the 3-week cultivation of these in vitro models

In particular, we noted significantly lower histological fibrosis scores, coupled with reduced collagen accumulation and expression of fibrotic genes and myofibroblast markers in the lung (Fig