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Methods: We employed biochemical studies, splicing reporter assays, and transcriptomic analyses to elucidate the function of GPATCH3

Many individuals with MTHFR variants experience no issues

While this could be related to GSH-mediated repair systems, it is also possible that GSH actively complexes free iron to prevent the Fenton reaction wherein hydrogen peroxide is dismutated to more reactive oxygen radicals that can damage proteins, lipids, and nucleic acids