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A National Cancer Institute screen found that the polycyclic aromatic compound NSC306711 blocked iron uptake by the Tf-TfR pathway and inhibited ferroptosis

Statements Author contributions WY: Conceptualization, Visualization, Writing original draft, Writing review & editing

2019;6(1):e000270

Future studies are still needed to further clarify the causal relationships of amino acid metabolism in autoimmune diseases and its hierarchical position in immune regulation through more systematic genetic studies, metabolic flux analyses, and single-cell multi-omics approaches, so as to distinguish its specific role as a disease driver or as a passenger/metabolic marker