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ALDH2 rs671 polymorphism may expedite the onset and progression of cardiovascular diseases by modulating biological processes such as autophagy, apoptosis, and oxidative stress in cardiomyocytes and VSMCs through ROS-mediated lipid peroxidation (99)

LindefeldtMEngADarbanHBjerknerAZetterstromCKAllanderTet al

Morita K, Wang F, Patel K, Bueso-Ramos C, IssaGC, Song X, Zhang J, Tippen S, Thornton R, Coyle M, Little L, Gumbs C, Ravandi F, Kadia T, Daver N, Konopleva M, Andreeff M , Cortes JE, Garcia-Manero G, Jabbour EJ, Futreal A, Kantarjian HM, Takahashi

Vardenafil could also enhance the delivery and therapeutic efficacy of herceptin monoclonal antibodies in mouse models of metastatic HER2/neu-positive brain tumors through stimulating caveolae-mediated endocytosis and micropinocytosis [92]