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Interestingly, anti-HSP autoantibodies are also found in healthy individuals, likely as a result of prior bacterial infections or tissue degradation

In this way, a specific interaction is established between autoreactive B cells and CAR-T, allowing the selective elimination of various types of autoreactive B cells that recognize citrullinated autoantigens, such as vimentin, type II collagen, fibrinogen and tenascin-C13 ( Another promising approach involves the induction of tolerance in the synovial cavity of joints by CAR-T reg cells