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Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction

Ozone therapy is discussed as a controlled redox signal that may affect oxygen utilization, antioxidant response and mitochondrial energy production

Activation of PPAR by acupuncture may support myelin regeneration and reduce peroxisome-mediated lipid peroxidation, thereby preventing ferroptosis while sustaining neuronal function

Overall, this review aims to provide a mechanistic and practical foundation for the development of next-generation protein-based transporters for microbiota-targeted therapies