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S2) UniFrac analyses and BrayCurtis dissimilarity analysis (Supplementary Fig

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Due to change in size and shape, the movement of red blood cells from bone marrow to the bloodstream become ineffective, often leading to megaloblastic anemia

Pros of B12 Oral Sprays: Up to 90% absorption rate (comparable to injections) Completely painless and non-invasive No needles, no medical appointments Convenient daily use at home Travel-friendly and portable More affordable long-term Can use methylcobalamin (superior bioavailability) Pleasant taste (raspberry flavor) No risk of infection Cons of B12 Oral Sprays: Requires daily consistency Must hold under tongue for 30-60 seconds May not be suitable for extremely severe deficiency requiring immediate correction Absorption Comparison One of the biggest myths about B12 supplementation is that injections are the only way to achieve high absorption