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The peptide also increases elastin production by 30% and dramatically upregulates decorin, a proteoglycan that regulates collagen organization

It can lead to symptoms such as pain, tingling, numbness, burning, weakness, or balance problems

A 2021 review of NNMT as a metabolic target stated plainly that clinical trials targeting NNMT have not been reported until now (Liu 2021, PMID 34368359) [5], and that held into 2026