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Understanding the Fraught History of the Drug Isotretinoin was originally studied and patented in 1969 by Roche Laboratories as a possible treatment for skin cancer

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doi:10.1016/j.mad.2005.01.005 436. Jeyaratnaganthan N, Hjlund K, Kroustrup JP, Larsen JF, Bjerre M, Levin K, Beck-Nielsen H, Frago S, Hassan AB, Flyvbjerg A, et al