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Subsequently many other mutations were found to be associated with familial forms of PD (Flagmeier et al., 2016) including the A30P mutant aggravating PD by reduced autophagic clearance of protein aggregates (Lei et al., 2019) and E46K mutant which promotes fibrillation of N acetylated -synuclein by abolishing the long-range electrostatic interactions (Zhao et al., 2020)

Curcumin enhances the anti- Trypanosoma cruzi activity of benznidazole-based chemotherapy in acute experimental chagas disease

therefore, inhibiting this inflammation, induced by MSU crystals, may present a therapeutic approach to managing HUA and related complications (65)