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Recently, there has been a great improvement in assay methods and measurement accuracy for biomarkers of oxidative stress, which have been correlated with disease activity and progression of disease, however this has not been validated in the clinic

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Furthermore, factors such as innate immune responses, coagulopathy, the modulation of the anti-inflammatory/pro-inflammatory equilibrium, and immunosuppression, collectively play a role in the onset and progression of septic shock, potentially leading to organ dysfunction [98]

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