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SKU: 57092951475
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It was found that MDR glioblastoma cells displayed lower levels of endogenous ROS and high levels of GSH

ClusPro was used to conduct automated docking between the two molecules

118 Accumulation of fumarate inhibits the KDM5 family of histone demethylases, increasing the levels of the active gene transcription marker H3K4me3

Moreover, a minor proportion of this agent can be metabolized within the liver by the cytochrome P450 enzymes (primarily by CYP2E1) to NAPQI, which is detoxified by conjugation and excreted in the glutathione or NAC forms ( Figure 2 )