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Description

Dysregulated inflammatory mediators and microbial products, such as cytokines (e.g., TNF, IFN, IL-1, IL-22) and endotoxins, are closely linked to barrier dysfunction and impaired intestinal homeostasis [10]

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Originally all melatonin was derived from the pineal gland of cows, sheep, or pigs

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Thats not only because some patients dont respond well to the treatment but also because the drug should be avoided altogether (or at least used with extreme caution) in some cases

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