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Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]

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261 Statins also have renoprotective effects by reducing albuminuria and preserving the glomerular filtration rate

The therapy is generally a safe one and does not involve any risks as well as complications