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Biological effects of propionic acid in humans

High baseline AR abundance and activity was required for growth inhibition by SPA, as inducible shRNA-mediated knock-down of AR in LNCaP cells (Figure 1B) resulted in resistance to SPA (Figure 1C) and rescued clonogenic survival following SPA treatment (Supplemental Figure 2)

[DOI] [PubMed] [Google Scholar] 9.Lammert F, Gurusamy K, Ko CW, Miquel JF, Mendez-Sanchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ