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Turkish Journal of Thoracic and Cardiovascular Surgery 26(1):2229 Pastoris O, Dossena M, Foppa P, Catapano M, Arbustini E, Bellini O, Dal Bello B, Minzioni G, Ceriana P, Barzaghi N (1998) Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery

Gene symbols (italicized) indicate human transcripts (e.g., PRDX2, PPARA )

On the other hand, oxidative mtDNA is released into the cytoplasm due to the elevated MMP, triggering innate immune responses, such as NLRP3 activation, and subsequently leading to the upregulation of inflammatory factors like IL-1 [16]