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Description

Edwards DJ, Burns MO

Dysautonomia, POTS, and the hEDS patient with a long list of symptoms and conditions

301 Under normoxia, HIF-1 is hydroxylated by prolyl-hydroxylases (PHDs) and then recognized and degraded by the ubiquitinproteasome system, maintaining its low intracellular levels

ROS accumulation disrupts insulin signaling by inhibiting insulin receptor substrate (IRS) proteins, which subsequently reduces the translocation of glucose transporter type 4 (GLUT4) to the plasma membrane and lowers glucose uptake in peripheral tissues such as muscle and adipose tissue