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Chronic hyperglycemia in T2DM has been reported to induce significant alterations in DNA methylation, subsequently resulting in increased risks of cardiovascular dysfunction [111, 114,115,116] by promoting oxidative stress, atherosclerosis, endothelial dysfunction and dysregulated lipid metabolism

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Guo F, Guo Y, Zhang D, Fu Z, Han S, Wan Y et al (2024) Luteolin inhibits the JAK/STAT pathway to alleviate auditory cell apoptosis of acquired sensorineural hearing loss based on network pharmacology, molecular docking, molecular dynamics simulation, and experiments in vitro

To quantify A 42 peptides, the human A 42 Ultrasensitive ELISA Kit (Invitrogen) was used according to manufacturers instructions