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[158] [159] [160] [161] [162] Atypical antipsychotics e.g., quetiapine, and asenapine are relatively potent antagonists of 5-HT 2A Brexpiprazole an atypical antipsychotic, is a potent antagonist at 5-HT 2A receptors (K i = 0.47 nM in humans)

Subsequent interest in AOD-9604 has been limited to niche research areas, particularly osteoarthritis, where intra-articular injection might bypass systemic bioavailability limitations

The addition of ImmTOR to pegadricase results in a dose-dependent reduction in ADAs corresponding with prolonged serum enzyme activity and maintenance of low sUA levels