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Animal and in vitro studies robustly demonstrate that polyphenols modulate epigenetic regulators (e.g., microRNAs, HDAC activity, DNA methylation) and fibrotic pathways such as TGF-/SMAD, yet these mechanisms have not been systematically validated in well-controlled human oncology trials that concurrently assess molecular, structural, and functional endpoints

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METTL3, aided by YTHDF2, diminishes both the stability and expression of the cell fusion-specific gene Atp6v0d2 mRNA

Wittchen, H