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It is important to note that nNOS activity was increased significantly in ischemic stroke modles, which may lead to neuroexcitotoxicity of glutamate in mesocorticolimbic areas ( Evidence That Hyperglutamatergic State Causes Neuroexcitotoxicity In the late 1960s and early 1970s, it was found that sustained exposure to glutamate and other excitatory amino acids may cause neuronal damage [for review refer to Olney, 1986)

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