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Treatment of macrophage cells such as differentiated bone marrow-derived macrophages and J774A.1 murine macrophages with recombinant CHBP resulted in rapid cell death, while leaving epithelial cells such as HeLa cells viable [Citation154]

Although the mechanism(s) underlying NASH progression remain to be fully elucidated, accumulating evidence suggests that both oxidative stress and the pro-inflammatory cytokine tumor necrosis factor- (TNF) are critical contributors in this process 5

These procedures work best when combined with strict sun protection and maintenance topicals