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Swertia cincta and its main active ingredients regulate the PPAR- pathway in anti-cholestatic liver injury

Luo et al., Open Questions and Conclusions While robust experimental evidence exists that thrombin affects brain functioning through the concentration-dependent regulation of distinct forms of synaptic plasticity, it remains unclear how thrombin exerts such diverse effects by acting on the same receptor, i.e., via PAR1

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This surplus of ATP likely enables futile cycles like the creatine cycle (which is upregulated in Alas1 KO cells and BAKO mice, Figure 1h and 2i ) to function more effectively and may account for the higher uncoupled respiration in Alas1 KO + HA compared to Alas1 KO cells ( Figure 3b ), even though the levels of UCP1 remain unchanged between these two conditions ( Figure 3d and e )