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RAS functions as a guanosine diphosphate (GDP)/triphosphate (GTP) binary switch, which controls important signal transduction from activated membrane receptors to intracellular molecules 22 The binary switch is mainly determined by two kinds of regulatory proteins: guanine nucleotide exchange factors (GEFs) such as son of sevenless (SOS) and GTPase-activating proteins (GAPs) such as neurofibromin 1 (NF1) 23

Methods Compounds for high-throughput screening For the similarity search and expanded screening, a diverse library of small-molecule compounds (1,000,000) from Asinex, Enamine and in-house collection was used

May support general energy levels and overall recovery after exercise

Yoo Du-yeol , our role is to help patients make informed decisionsespecially when the treatment may pose long-term risks