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Description

This heightened oxidative burden extends beyond immune cells to the airway epithelial cells, which are primary sites of CFTR dysfunction (Regelmann et al., 1991)

Protein kinase C (PKC) activators (PMA), HDAC and DNA methyl transferase (DNMT) inhibitors, chemotherapeutic agents and anti-IgG are among the known classes of lytic inducers

DALY rates increased from 2.32 (95% UI, 0.30 to 5.95) per 100,000 in 1990 to 2.70 (95% UI, 0.36 to 6.83) per 100,000 in 2021, an increase of 16.26% (95% UI, 8.0427.07), with an EAPC of 0.50 (95% CI, 0.390.62)