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They can be coenzymes in various reactions (B vitamins, vitamins A and K) and/or antioxidants that protect the cell and its membrane from free radicals (vitamins C and E)

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Conversely, recovering GSH levels with precursors of its synthesis, such as N-acetyl-cysteine or 2-oxothiazolidine-4-carboxylic acid, increase the protective effects

Urinary histamine levels can be increased in certain inflammatory conditions including interstitial cystitis, thereby making plasma and urinary histamine unreliable biomarkers for measurement of mast cell activation