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These criteria have been criticized for their lack of specificity and of supporting evidence to link such a broad range of symptoms to chronic mast cell activation [4, 7, 1012]

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For example, a frank deficiency in Ca 2+ intake leads to bone loss even though blood Ca 2+ levels remain normal

Arabidopsis histone methyltransferase SET DOMAIN GROUP8 mediates induction of the jasmonate/ethylene pathway genes in plant defense response to necrotrophic fungi