glutathione s-transferase uniprot GST-Tag Glutathione S Information on EC 2.7.7.12 -

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Meeting Cellular Needs : [1] When the requirement for Ribose-5-phosphate exceeds the need for NADPH (a) Non-Oxidative Branch: reversed to produce Ribose-5-phosphate (nucleic acid precursor) (b) Oxidative Branch: shut-down, no NADPH production [2] When the requirement for NADPH exceeds the need for Ribose-5-phosphate (a) Oxidative Branch: will be activated (b) Non-Oxidative Branch: Ribose-5-phosphate will be converted to Glyceraldehyde-3- phosphate and Fructose-6-phosphate which will enter the glycolytic pathway for metabolism to pyruvate (this eliminates "feedback" inhibition by Ribose-5- phosphate which would inactivate the Oxidative Branch)

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