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One aspect of this study that may be missed are the overall excellent responses achieved with only a moderate dose of methotrexate, highlighting the potency of methotrexate as a DMARD which can often be overlooked in clinical trials that typically enroll only subjects with inadequate responses to methotrexate

Another 0.7 million beneficiaries are estimated to have drug coverage through employer-sponsored retiree plans where the employer receives a subsidy from the federal government equal to 28% of drug expenses between $615 and $12,650 per retiree in 2026

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So, while the explanation touches on real aspects of neuropathy and B12 deficiency, it might oversimplify or misrepresent some of the complex interactions in the nervous system