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Description

A DNA aptamer for binding and inhibition of DNA methyltransferase 1

The latter is the leading cause of premature mortality in Friedreichs ataxia 170

After elucidating the molecular structure of succinicGSH, we confirmed its presence in Fh1 / cells using targeted LC-MS, showing that succinicGSH represents about 10% of the total GSH in these cells (Fig