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NAC, -tocopherol, and -lipoic acid, which are well-known antioxidants proved to be able to cross BBB and to achieve a neuroprotective effect, were shown to restrain oxidative stress and damage and reverse the axonal degeneration and dyskinesia in combination in the preclinical study ( As an agonist of PPAR, pioglitazone reverses mitochondrial depletion and bioenergy failure via the activation of the PGC-1/PPAR pathway and reduces oxidized damage of DNA as well as proteins through antioxidative action, preventing the progression of axonal degeneration and locomotor deficits (88)

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Chator C, Chevrier M, Frenel J-S, Guyon F, Sabatier R, Pomel C, et al

Melanin is the pigment that determines the colour of your skin, hair, and other aspects of your appearance