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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model

Targeting neuroinflammatory pathways is now recognized as a promising therapeutic strategy, with potential benefits including restoration of neuronal function, promotion of neuroregeneration, and mitigation of A and tau toxicity ( 4.3 Challenges of current FDA approved treatments Despite continuous research efforts, the efficacy of current FDA-approved drugs remains limited

Signals were quantified using Image Lab (Bio-Rad)

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