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In our study, we did not observe an increase in loose stools in NAC-treated animals during daily monitoring, consistent with previous research showing no toxicity after 30 days of high-dose NAC (1200 mg/kg/day) in rats [109]

Consistently, in neurodegenerative diseases it was observed an imbalance in the signaling pathway of HO-1 induction, leading to the loss of normal tissues and immune homeostasis, cellular deterioration and progressive development of neurodegeneration (114)

Furthermore, no RIPK1 activation was observed in HK1-deficient cells stimulated with TNF alone or TNF/CHX (Supplementary Fig

Melasma is influenced by hormones, sun exposure, and inflammation, so treating it often requires a multi-layered approach